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| Cat.No | ACP18250 | Target Name | TTLL4 |
|---|---|---|---|
| Target Synonyms | TTLL4; TTLL4_HUMAN; Tubulin polyglutamylase TTLL4; Tubulin--tyrosine ligase-like protein 4 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q14679 |
|---|
Uniprot Id
Q14679
Target Species
Human
Target Name
TTLL4
Target Full Name
Tubulin monoglutamylase TTLL4
Target Function
Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis
Target Subcellular Location
Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body.
Target Protein Families
Tubulin--tyrosine ligase family
Target Synonyms
TTLL4; TTLL4_HUMAN; Tubulin polyglutamylase TTLL4; Tubulin--tyrosine ligase-like protein 4
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