Recombinant Human Toll-like receptor 9 (TLR9), Truncated

Cat.No	ACP18906	Target Name	TLR9
Target Synonyms	CD 289; CD289; TLR 9; TLR9; TLR9_HUMAN; Toll like receptor 9; Toll like receptor 9 isoform A precursor; Toll like receptor 9 isoform B; Toll-like receptor 9	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP18906

Target Name

TLR9

Target Synonyms

CD 289; CD289; TLR 9; TLR9; TLR9_HUMAN; Toll like receptor 9; Toll like receptor 9 isoform A precursor; Toll like receptor 9 isoform B; Toll-like receptor 9

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NR96

Background Information

Uniprot Id

Q9NR96
Target Species

Human
Target Name

TLR9
Target Full Name

Toll-like receptor 9
Target Function

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome.
Target Protein Families

Toll-like receptor family
Target Tissue Specificity

Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
Target Synonyms

CD 289; CD289; TLR 9; TLR9; TLR9_HUMAN; Toll like receptor 9; Toll like receptor 9 isoform A precursor; Toll like receptor 9 isoform B; Toll-like receptor 9
Target Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

Recombinant Human Toll-like receptor 9 (TLR9), Truncated

Specifications

Immunogen Information

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