Recombinant Human BBSome-interacting protein 1 (BBIP1)

Uniprot Id

A8MTZ0

Target Species

Human

Target Name

BBIP1

Target Full Name

BBSome-interacting protein 1

Target Function

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for primary cilia assembly and BBSome stability. Regulates cytoplasmic microtubule stability and acetylation

Target Involvement

Bardet-Biedl syndrome 18 (BBS18)

Target Subcellular Location

Cell projection, cilium. Cytoplasm. Note=Localizes inside the primary cilium but not at centriolar satellites.

Target Protein Families

BBIP10 family

Target Synonyms

BBIP1; BBIP10; NCRNA00081BBSome-interacting protein 1; BBSome-interacting protein of 10 kDa