Recombinant Human Splicing factor, arginine/serine-rich 15 (SCAF4), Truncated

Uniprot Id

O95104

Target Species

Human

Target Name

SCAF4

Target Full Name

SR-related and CTD-associated factor 4

Target Function

Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough.

Target Subcellular Location

Nucleus.

Target Protein Families

Splicing factor SR family

Target Synonyms

SCAF4; KIAA1172; SFRS15; SR-related and CTD-associated factor 4; CTD-binding SR-like protein RA4; Splicing factor; arginine/serine-rich 15

Target Background

This gene likely encodes a member of the arginine/serine-rich splicing factor family. A similar protein in Rat appears to bind the large subunit of RNA polymerase II and provide a link between transcription and pre-mRNA splicing. Alternatively spliced transcript variants have been described.