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| Cat.No | ACP24479 | Target Name | H2AFB1 |
|---|---|---|---|
| Target Synonyms | H2AB1; H2AFB1; Histone H2A-Bbd type 1; H2A Barr body-deficient; H2A.B; H2A.Bbd | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-115 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P0C5Y9 |
|---|
Uniprot Id
P0C5Y9
Target Species
Human
Target Name
H2AB1
Target Full Name
Histone H2A-Bbd type 1
Target Function
Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing.
Target Subcellular Location
Nucleus. Chromosome.
Target Protein Families
Histone H2A family
Target Tissue Specificity
Present in mature sperm.
Target Synonyms
H2AB1; H2AFB1; Histone H2A-Bbd type 1; H2A Barr body-deficient; H2A.B; H2A.Bbd
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