Recombinant Human Homeobox protein Nkx-6.1 (NKX6-1)

Uniprot Id

P78426

Target Species

Human

Target Name

NKX6-1

Target Full Name

Homeobox protein Nkx-6.1

Target Function

Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Pancreatic beta cells.

Target Synonyms

Homeobox protein NK-6 homolog A; Homeobox protein Nkx-6.1; NK homeo box, family 6, member A ; NK homeobox (Drosophila), family 6, A; NK homeobox, family 6, A ; NK6 homeobox 1; NK6 transcription factor homolog A ; NK6 transcription factor related, locus 1 ; NK6 transcription factor related, locus 1 (Drosophila); NKX6-1; NKX6.1; NKX61; NKX61_HUMAN; NKX6A

Target Background

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].