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The antibody against DIS3L was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DIS3L (NP_588616.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against DIS3L was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DIS3L (NP_588616.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-04597A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DIS3L |
| Target Synonyms | DIS3L1; DIS3L | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse testis, Rat thymus, U-87MG | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DIS3L (NP_588616.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8TF46 | Immunogen Sequence |
Uniprot Id
Q8TF46
Target Species
Human
Target Name
DIS3L
Target Full Name
DIS3-like exonuclease 1
Target Function
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
Target Subcellular Location
Cytoplasm.
Target Protein Families
RNR ribonuclease family
Target Synonyms
DIS3L; DIS3L1; KIAA1955DIS3-like exonuclease 1; EC 3.1.13.-
Target Background
The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex.
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