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The antibody against HPS4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 387-708 of human HPS4 (NP_071364.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against HPS4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 387-708 of human HPS4 (NP_071364.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-04599A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HPS4 |
| Target Synonyms | LE; BLOC3S2; HPS4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | U-87MG | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 387-708 of human HPS4 (NP_071364.4). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NQG7 | Immunogen Sequence |
Uniprot Id
Q9NQG7
Target Species
Human
Target Name
HPS4
Target Full Name
BLOC-3 complex member HPS4
Target Function
Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38.
Target Involvement
Hermansky-Pudlak syndrome 4 (HPS4)
Target Synonyms
HPS4; KIAA1667; Hermansky-Pudlak syndrome 4 protein; Light-ear protein homolog
Target Background
This gene encodes a protein component of biogenesis of lysosome-related organelles complexes (BLOC). BLOC complexes are important for the formation of endosomal-lysosomal organelles such as melanosomes and platelet dense granules. Mutations in this gene result in subtype 4 of Hermansky-Pudlak syndrome, a form of albinism. Alternative splicing results in multiple transcript variants.
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