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The antibody against CHRD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 686-955 of human CHRD (NP_003732.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CHRD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 686-955 of human CHRD (NP_003732.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06945A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CHRD |
| Target Synonyms | CHRD | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse liver, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 686-955 of human CHRD (NP_003732.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H2X0 | Immunogen Sequence |
Uniprot Id
Q9H2X0
Target Species
Human
Target Name
CHRD
Target Full Name
Chordin
Target Function
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
Target Subcellular Location
Secreted.
Target Protein Families
Chordin family
Target Tissue Specificity
Expressed at the highest level in liver.
Target Synonyms
CHRD; UNQ217/PRO243Chordin
Target Background
This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined.
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