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The antibody against ADHFE1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 41-255 of human ADHFE1(NP_653251.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ADHFE1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 41-255 of human ADHFE1(NP_653251.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-08498A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ADHFE1 |
| Target Synonyms | HOT; ADH8; HMFT2263 | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 41-255 of human ADHFE1(NP_653251.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8IWW8 | Immunogen Sequence |
Uniprot Id
Q8IWW8
Target Species
Human
Target Name
ADHFE1
Target Full Name
Hydroxyacid-oxoacid transhydrogenase, mitochondrial
Target Function
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.
Target Subcellular Location
Mitochondrion.
Target Protein Families
Iron-containing alcohol dehydrogenase family, Hydroxyacid-oxoacid transhydrogenase subfamily
Target Tissue Specificity
Only expressed in adult liver.
Target Synonyms
ADH8; ADHFE 1; ADHFe1; Alcohol dehydrogenase iron-containing protein 1; Alcohol dehydrogenase; iron containing; 1; Fe containing alcohol dehydrogenase; Fe-containing alcohol dehydrogenase; HOT; HOT_HUMAN; Hydroxyacid oxoacid transhydrogenase; mitochondrial; Hydroxyacid-oxoacid transhydrogenase; mitochondrial
Target Background
The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).
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