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The antibody against PDE1A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 446-545 of human PDE1A (NP_005010.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PDE1A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 446-545 of human PDE1A (NP_005010.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10359A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDE1A |
| Target Synonyms | HCAM1; HCAM-1; HSPDE1A; CAM-PDE 1A; CAM-PDE-1A; PDE1A | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Mouse kidney, Rat brain, Rat heart, Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 446-545 of human PDE1A (NP_005010.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | EASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNSEDLVNAEEKHDETHS | Uniprot ID | P54750 |
Uniprot Id
P54750
Target Species
Human
Target Name
PDE1A
Target Full Name
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Target Function
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
Target Protein Families
Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
Target Tissue Specificity
Several tissues, including brain, kidney, testes and heart.
Target Synonyms
HCAM1; HCAM-1; HSPDE1A; CAM-PDE 1A; CAM-PDE-1A; PDE1A
Target Background
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).
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