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The antibody against HTR4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 350-384 of human HTR4 (NP_000861.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against HTR4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 350-384 of human HTR4 (NP_000861.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10551A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HTR4 |
| Target Synonyms | 5-HT4; 5-HT4R; HTR4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Jurkat, Mouse brain, small intestine | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 350-384 of human HTR4 (NP_000861.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | TINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQ | Uniprot ID | Q13639 |
Uniprot Id
Q13639
Target Species
Human
Target Name
HTR4
Target Full Name
5-hydroxytryptamine receptor 4
Target Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Endosome.
Target Protein Families
G-protein coupled receptor 1 family
Target Tissue Specificity
Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle.
Target Synonyms
HTR4; 5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; Serotonin receptor 4
Target Background
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
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