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The antibody against ALKBH7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human ALKBH7 (NP_115682.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ALKBH7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human ALKBH7 (NP_115682.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-11299A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ALKBH7 |
| Target Synonyms | ABH7; SPATA11; UNQ6002; ALKBH7 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | K-562, LO2, Mouse pancreas | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human ALKBH7 (NP_115682.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BT30 | Immunogen Sequence |
Uniprot Id
Q9BT30
Target Species
Human
Target Name
ALKBH7
Target Full Name
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
Target Function
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
AlkB family
Target Tissue Specificity
Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.
Target Synonyms
ALKBH7; ABH7; SPATA11; UNQ6002/PRO34564; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7; mitochondrial; EC 1.14.11.-; Alkylated DNA repair protein alkB homolog 7; Spermatogenesis cell proliferation-related protein; Spermatogenesis-associated protein 11
Target Background
Predicted to enable dioxygenase activity and metal ion binding activity. Involved in cellular response to DNA damage stimulus and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Located in mitochondrial matrix.
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