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The antibody against GAD65/GAD2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-125of human GAD65/GAD2 (NP_000809.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against GAD65/GAD2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-125of human GAD65/GAD2 (NP_000809.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-15027A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GAD65/GAD2 |
| Target Synonyms | GAD65; GAD65/GAD2 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse brain, Mouse liver(Negative control) | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-125of human GAD65/GAD2 (NP_000809.1). | Immunogen Sequence | MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKS |
|---|---|---|---|
| Uniprot ID | Q05329 |
Uniprot Id
Q05329
Target Species
Human
Target Name
GAD2
Target Full Name
Glutamate decarboxylase 2
Target Function
Catalyzes the production of GABA.
Target Subcellular Location
Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
Target Protein Families
Group II decarboxylase family
Target Synonyms
GAD65; GAD65/GAD2
Target Background
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
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