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The antibody against AGXT2 was raised in Rabbit using the recombinant protein of human AGXT2 as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against AGXT2 was raised in Rabbit using the recombinant protein of human AGXT2 as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-08264A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AGXT2 |
| Target Synonyms | AGT2; BAIBA; DAIBAT; AGXT2 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, WB |
| Immunogen Description | Recombinant protein of human AGXT2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BYV1 |
Uniprot Id
Q9BYV1
Target Species
Human
Target Name
AGXT2
Target Full Name
Alanine--glyoxylate aminotransferase 2, mitochondrial
Target Function
Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.
Target Subcellular Location
Mitochondrion.
Target Protein Families
Class-III pyridoxal-phosphate-dependent aminotransferase family
Target Synonyms
AGXT2; AGT2Alanine--glyoxylate aminotransferase 2; mitochondrial; AGT 2; EC 2.6.1.44,; R)-3-amino-2-methylpropionate--pyruvate transaminase; EC 2.6.1.40; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-AIBAT
Target Background
The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants.
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