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The antibody against ALKBH2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human ALKBH2 (NP_001138847.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ALKBH2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human ALKBH2 (NP_001138847.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03074A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ALKBH2 |
| Target Synonyms | ABH2; ALKBH2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, HepG2, MCF7 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human ALKBH2 (NP_001138847.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6NS38 | Immunogen Sequence |
Uniprot Id
Q6NS38
Target Species
Human
Target Name
ALKBH2
Target Full Name
DNA oxidative demethylase ALKBH2
Target Function
Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
Target Subcellular Location
Nucleus. Note=Detected in replication foci during S-phase.
Target Protein Families
AlkB family
Target Tissue Specificity
Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
2OG Fe(II) oxy DC1; 9530023G02 ; ABH 2; ABH2; alkB alkylation repair homolog 2; ALKB2_HUMAN; ALKBH2 alkB; ALKBH2; Alkylated DNA repair protein alkB homolog ; Alkylated DNA repair protein alkB homolog 2; Alkylation repair homolog 2; Alpha ketoglutarate dependent dioxygenase alkB homolog 2; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; AU016977; DNA oxidative demethylase ALKBH2; EC 1.14.11.; FLJ99103; hABH2; mABH2; MGC90512 ; Oxy DC1
Target Background
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).
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