Rabbit anti-Human AP1S1 Polyclonal Antibody

Uniprot Id

P61966

Target Species

Human

Target Name

AP1S1

Target Full Name

AP-1 complex subunit sigma-1A

Target Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Target Involvement

Mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma (MEDNIK)

Target Subcellular Location

Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Target Protein Families

Adaptor complexes small subunit family

Target Tissue Specificity

Widely expressed.

Target Synonyms

Adapter related protein complex 1 sigma 1A subunit; Adapter-related protein complex 1 sigma-1A subunit; Adaptor protein complex AP-1 sigma-1A subunit; Adaptor protein complex AP1 sigma 1A subunit; AP-1 complex subunit sigma-1A; AP1 complex subunit sigma 1A; AP19; AP1S1; AP1S1_HUMAN; CLAPS1; Clathrin assembly protein complex 1 sigma 1A small chain; Clathrin assembly protein complex 1 sigma-1A small chain; Clathrin coat assembly protein AP19; Golgi adaptor HA1/AP1 adaptin sigma 1A subunit; Golgi adaptor HA1/AP1 adaptin sigma-1A subunit; HA1 19 kDa subunit; Sigma 1a subunit of AP-1 clathrin; Sigma 1a subunit of AP1 clathrin; Sigma adaptin 1A; Sigma-adaptin 1A; Sigma1A adaptin; Sigma1A-adaptin

Target Background

The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle.