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The antibody against ATF7IP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 525-725 of human ATF7IP (NP_060649.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ATF7IP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 525-725 of human ATF7IP (NP_060649.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01530A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ATF7IP |
| Target Synonyms | AM; MCAF; p621; MCAF1; ATF-IP; ATF7IP1; ATF7IP | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, A-549, MCF7 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 525-725 of human ATF7IP (NP_060649.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6VMQ6 | Immunogen Sequence |
Uniprot Id
Q6VMQ6
Target Species
Human
Target Name
ATF7IP
Target Full Name
Activating transcription factor 7-interacting protein 1
Target Function
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells
Target Subcellular Location
Nucleus.
Target Protein Families
MCAF family
Target Tissue Specificity
Detected at low levels in breast, lung and stomach; highly up-regulated in the corresponding cancerous tissues (at protein level).
Target Synonyms
ATF7IP; MCAF; MCAF1Activating transcription factor 7-interacting protein 1; ATF-interacting protein; ATF-IP; ATF7-interacting protein; ATFa-associated modulator; hAM; MBD1-containing chromatin-associated factor 1; P621
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