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The antibody against ATP10A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 440-690 of human ATP10A (NP_077816.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ATP10A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 440-690 of human ATP10A (NP_077816.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04778A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ATP10A |
| Target Synonyms | ATPVA; ATPVC; ATP10C; ATP10A | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-431, A-549, DU-145, HT-29, OVCAR3, U-251MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 440-690 of human ATP10A (NP_077816.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O60312 | Immunogen Sequence |
Uniprot Id
O60312
Target Species
Human
Target Name
ATP10A
Target Full Name
Phospholipid-transporting ATPase VA
Target Function
Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer).
Target Involvement
Angelman syndrome (AS)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.
Target Protein Families
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
Target Tissue Specificity
Widely expressed, with highest levels in kidney, followed by lung, brain, prostate, testis, ovary and small intestine.
Target Synonyms
ATP10A; ATP10C; ATPVA; ATPVC; KIAA0566Probable phospholipid-transporting ATPase VA; EC 7.6.2.1; ATPase class V type 10A; Aminophospholipid translocase VA; P4-ATPase flippase complex alpha subunit ATP10A
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