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The antibody against BCO2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 170-410 of human BCO2 (NP_001243327.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against BCO2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 170-410 of human BCO2 (NP_001243327.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03865A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BCO2 |
| Target Synonyms | BCDO2; B-DIOX-II; BCO2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T, LO2, Mouse liver, Rat liver, SGC-7901, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 170-410 of human BCO2 (NP_001243327.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BYV7 | Immunogen Sequence |
Uniprot Id
Q9BYV7
Target Species
Human
Target Name
BCO2
Target Full Name
Carotenoid-cleaving dioxygenase, mitochondrial
Target Function
Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects.
Target Subcellular Location
Mitochondrion.
Target Protein Families
Carotenoid oxygenase family
Target Tissue Specificity
Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level).
Target Synonyms
B-diox-II; BCDO2_HUMAN; Bco2; Beta,beta-carotene 9',10'-oxygenase; Beta-carotene dioxygenase 2
Target Background
This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene.
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