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The antibody against CAST was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 406-695 of human CAST (NP_001177371.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
The antibody against CAST was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 406-695 of human CAST (NP_001177371.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
Immunohistochemistry analysis of CAST in paraffin-embedded human breast cancer using CAST Rabbit pAb at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
| Cat.No | ADA-04352A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CAST |
| Target Synonyms | BS-17; PLACK; CAST | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 406-695 of human CAST (NP_001177371.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P20810 | Immunogen Sequence |
Uniprot Id
P20810
Target Species
Human
Target Name
CAST
Target Full Name
Calpastatin
Target Function
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Target Involvement
Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK)
Target Protein Families
Protease inhibitor I27 (calpastatin) family
Target Research Area
Neuroscience
Target Synonyms
BS 17; Calpain inhibitor; Calpastatin; Cast; Heart type calpastatin ; ICAL_HUMAN; MGC9402; Sperm BS 17 component ; Sperm BS-17 component
Target Background
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
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