Rabbit anti-Human CIT Polyclonal Antibody

The antibody against CIT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1000-1300 of human CIT (NP_001193928.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-09795A

Number

Cat.No	ADA-09795A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CIT
Target Synonyms	CITK; CRIK; STK21; MCPH17; CIT	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Mouse kidney, Jurkat, Mouse testis, Mouse thymus, U-87MG	Application	ELISA, WB

Cat.No

ADA-09795A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CIT

Target Synonyms

CITK; CRIK; STK21; MCPH17; CIT

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Mouse kidney, Jurkat, Mouse testis, Mouse thymus, U-87MG

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1300 of human CIT (NP_001193928.1).	Target Species	Human
Uniprot ID	O14578	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1300 of human CIT (NP_001193928.1).

Target Species

Human

Uniprot ID

O14578

Immunogen Sequence

Background Information

Uniprot Id

O14578
Target Species

Human
Target Name

CIT
Target Full Name

Citron Rho-interacting kinase
Target Function

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Target Involvement

Microcephaly 17, primary, autosomal recessive (MCPH17)
Target Subcellular Location

Cytoplasm.
Target Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family
Target Synonyms

CIT; CRIK; KIAA0949; STK21Citron Rho-interacting kinase; CRIK; EC 2.7.11.1; Serine/threonine-protein kinase 21
Target Background

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.

Rabbit anti-Human CIT Polyclonal Antibody

Specifications

Immunogen Information

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