Rabbit anti-Human DEK Polyclonal Antibody

The antibody against DEK was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 50-160 of human DEK (NP_003463.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03628A

Number

Cat.No	ADA-03628A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	DEK
Target Synonyms	D6S231E; DEK	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse kidney, Rat brain, Mouse brain, U-251MG	Application	ELISA, WB

Cat.No

ADA-03628A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

DEK

Target Synonyms

D6S231E; DEK

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse kidney, Rat brain, Mouse brain, U-251MG

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 50-160 of human DEK (NP_003463.1).	Target Species	Human
Immunogen Sequence	KSLIVEGKREKKKVERLTMQVSSLQREPFTIAQGKGQKLCEIERIHFFLSKKKTDELRNLHKLLYNRPGTVSSLKKNVGQFSGFPFEKGSVQYKKKEEMLKKFRNAMLKSI	Uniprot ID	P35659

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 50-160 of human DEK (NP_003463.1).

Target Species

Human

Immunogen Sequence

KSLIVEGKREKKKVERLTMQVSSLQREPFTIAQGKGQKLCEIERIHFFLSKKKTDELRNLHKLLYNRPGTVSSLKKNVGQFSGFPFEKGSVQYKKKEEMLKKFRNAMLKSI

Uniprot ID

P35659

Background Information

Uniprot Id

P35659
Target Species

Human
Target Name

DEK
Target Full Name

Protein DEK
Target Function

Involved in chromatin organization.
Target Involvement

A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).
Target Subcellular Location

Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
Target Tissue Specificity

Ubiquitous. Expressed at relatively high levels.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

D6S231E; Dek; DEK gene; DEK oncogene; DEK oncogene DNA binding; DEK_HUMAN; Protein DEK
Target Background

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human DEK Polyclonal Antibody

Specifications

Immunogen Information

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