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The antibody against DET1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 15-240 of human DET1 (NP_060466.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DET1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 15-240 of human DET1 (NP_060466.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-08889A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DET1 |
| Target Synonyms | DET1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | BT-474, Mouse thymus | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 15-240 of human DET1 (NP_060466.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q7L5Y6 | Immunogen Sequence |
Uniprot Id
Q7L5Y6
Target Species
Human
Target Name
DET1
Target Full Name
DET1 homolog
Target Function
Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.
Target Subcellular Location
Nucleus.
Target Protein Families
DET1 family
Target Tissue Specificity
Highly expressed in the ovary, some lymphoid organs and resting leukocytes.
Target Synonyms
DET1; DET1 homolog; De-etiolated-1 homolog
Target Background
Enables ubiquitin ligase-substrate adaptor activity and ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Part of Cul4A-RING E3 ubiquitin ligase complex.
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