Rabbit anti-Human DNAJC7 Polyclonal Antibody

Uniprot Id

Q99615

Target Species

Human

Target Name

DNAJC7

Target Full Name

DnaJ homolog subfamily C member 7

Target Function

Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm.

Target Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.

Target Synonyms

DJ11; DJC7; DnaJ (Hsp40) homolog subfamily C member 7; DnaJ homolog subfamily C member 7; Dnajc7; DNJC7_HUMAN; Tetratricopeptide repeat domain 2; Tetratricopeptide repeat protein 2; TPR repeat protein 2; TPR2; TTC2

Target Background

This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.