Rabbit anti-Human DUSP2 Polyclonal Antibody

The antibody against DUSP2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 150-250 of human DUSP2 (NP_004409.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-10782A

Number

Cat.No	ADA-10782A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	DUSP2
Target Synonyms	PAC1; PAC-1; DUSP2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, NIH/3T3, 293T, MCF7	Application	ELISA, WB

Cat.No

ADA-10782A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

DUSP2

Target Synonyms

PAC1; PAC-1; DUSP2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, NIH/3T3, 293T, MCF7

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 150-250 of human DUSP2 (NP_004409.1).	Target Species	Human
Immunogen Sequence	ALPPTGDKTSRSDSRAPVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSG	Uniprot ID	Q05923

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 150-250 of human DUSP2 (NP_004409.1).

Target Species

Human

Immunogen Sequence

ALPPTGDKTSRSDSRAPVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSG

Uniprot ID

Q05923

Background Information

Uniprot Id

Q05923
Target Species

Human
Target Name

DUSP2
Target Full Name

Dual specificity protein phosphatase 2
Target Function

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
Target Subcellular Location

Nucleus.
Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Target Tissue Specificity

Expressed in hematopoietic tissues.
Target Synonyms

PAC1; PAC-1; DUSP2
Target Background

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.

Rabbit anti-Human DUSP2 Polyclonal Antibody

Specifications

Immunogen Information

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