Rabbit anti-Human EDC3 Polyclonal Antibody

Uniprot Id

Q96F86

Target Species

Human

Target Name

EDC3

Target Full Name

Enhancer of mRNA-decapping protein 3

Target Function

Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.

Target Involvement

Mental retardation, autosomal recessive 50 (MRT50)

Target Subcellular Location

Cytoplasm, P-body. Note=Processing bodies (PB).

Target Protein Families

EDC3 family

Target Tissue Specificity

Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division part II and apical membrane of Sertoli cells in testis (at protein level). Also expressed in brain and mammary gland.

Target Synonyms

EDC 3; edc3; EDC3_HUMAN; enhancer of mRNA decapping 3 homolog (S. cerevisiae); Enhancer of mRNA decapping 3 homolog; Enhancer of mRNA decapping 3; S. cerevisiae; homolog of; Enhancer of mRNA decapping protein 3; Enhancer of mRNA-decapping protein 3; FLJ21128; FLJ31777; hYjeF_N2; hYjeF_N2-15q23; LSM 16; LSM16; LSM16 homolog (EDC3 S. cerevisiae); LSM16 homolog (EDC3; S. cerevisiae); LSM16 homolog; YJDC; YjeF domain containing; YjeF domain containing protein 1; YjeF domain containing protein; YjeF domain-containing protein 1; YjeF N-terminal domain-containing protein 2; YjeF_N2; YJEFN2

Target Background

This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability.