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The antibody against EIF3I was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human EIF3I (NP_003748.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against EIF3I was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human EIF3I (NP_003748.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02941A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EIF3I |
| Target Synonyms | TRIP1; EIF3S2; TRIP-1; PRO2242; eIF3-p36; eIF3-beta; EIF3I | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Jurkat, LO2, NCI-H460 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human EIF3I (NP_003748.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q13347 | Immunogen Sequence |
Uniprot Id
Q13347
Target Species
Human
Target Name
EIF3I
Target Full Name
Eukaryotic translation initiation factor 3 subunit I
Target Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Target Subcellular Location
Cytoplasm.
Target Protein Families
EIF-3 subunit I family
Target Synonyms
eIF-3-beta; eIF3 beta; eIF3 p36; eIF3-beta; eIF3-p36; eIF3i; EIF3I_HUMAN; EIF3S2; EIF3S2; formerly; Eukaryotic translation initiation factor 3 subunit 2; Eukaryotic translation initiation factor 3 subunit 2 beta; Eukaryotic translation initiation factor 3 subunit I; eukaryotic translation initiation factor 3; subunit 2 (beta; 36kD; eukaryotic translation initiation factor 3; subunit 2 beta; 36kDa; eukaryotic translation initiation factor 3; subunit 2; formerly; eukaryotic translation initiation factor 3; subunit I; Predicted protein of HQ2242; PRO2242; TGF beta receptor interacting protein 1; TGF-beta receptor-interacting protein 1; TGFbeta receptor interacting protein 1; TGFbeta receptor-interacting protein 1; TRIP 1; TRIP-1; TRIP1
Target Background
Contributes to translation initiation factor activity. Involved in translational initiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex.
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