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The antibody against ELAC2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ELAC2 (NP_776065.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against ELAC2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ELAC2 (NP_776065.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-11779A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ELAC2 |
| Target Synonyms | ELC2; HPC2; COXPD17; ELAC2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | MCF7, NCI-H460 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ELAC2 (NP_776065.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BQ52 | Immunogen Sequence |
Uniprot Id
Q9BQ52
Target Species
Human
Target Name
ELAC2
Target Full Name
Zinc phosphodiesterase ELAC protein 2
Target Function
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
Target Involvement
Prostate cancer, hereditary, 2 (HPC2); Combined oxidative phosphorylation deficiency 17 (COXPD17)
Target Subcellular Location
Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Nucleus. Note=Mainly mitochondrial.
Target Protein Families
RNase Z family
Target Tissue Specificity
Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.
Target Synonyms
COXPD17; elaC homolog 2 (E. coli); ElaC homolog protein 2; elaC ribonuclease Z 2; elaC, E. coli, homolog of, 2; ELAC2; ELC2; FLJ10530; FLJ36693; FLJ42848; Heredity prostate cancer protein 2; HPC2; putative prostate cancer susceptibility protein HPC2/ELAC2; Ribonuclease Z 2; Ribonuclease Z, long form; Ribonuclease Z2; RNase Z 2; RNase Z2; RNase ZL; RNZ2_HUMAN; tRNA 3 endonuclease 2; tRNase Z (long form); tRNase Z 2; tRNase Z2; Zinc phosphodiesterase ELAC protein 2
Target Background
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
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