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The antibody against EME1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human EME1 (NP_689676.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against EME1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human EME1 (NP_689676.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01487A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EME1 |
| Target Synonyms | MMS4L; SLX2A; EME1 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse thymus, Rat thymus | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human EME1 (NP_689676.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96AY2 | Immunogen Sequence |
Uniprot Id
Q96AY2
Target Species
Human
Target Name
EME1
Target Full Name
Crossover junction endonuclease EME1
Target Function
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Target Subcellular Location
Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells.
Target Protein Families
EME1/MMS4 family
Target Research Area
Cell Biology
Target Synonyms
6820428D13; Crossover junction endonuclease EME1; EC 3.1.22.-; EME1; Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe); EME1; S. pombe; homolog of; 1; EME1_HUMAN; essential meiotic endonuclease 1 homolog 1 (S pombe); Essential Meiotic Endonuclease 1 Homolog 1; essential meiotic endonuclease 1 homolog 2; Essential meiotic endonuclease 1; S. pombe; homolog of; 1; FLJ31364; hMMS4; homolog of yeast EME1 endonuclease; MGC106543; MMS4 ; MMS4 homolog; MMS4L
Target Background
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.
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