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The antibody against EVC was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 743-992 of human EVC (NP_714928.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against EVC was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 743-992 of human EVC (NP_714928.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03156A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EVC |
| Target Synonyms | EVC1; EVCL; DWF-1; EVC | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 743-992 of human EVC (NP_714928.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P57679 | Immunogen Sequence |
Uniprot Id
P57679
Target Species
Human
Target Name
EVC
Target Full Name
EvC complex member EVC
Target Function
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development.
Target Involvement
Ellis-van Creveld syndrome (EVC); Acrofacial dysostosis, Weyers type (WAD)
Target Subcellular Location
Cell membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cell projection, cilium membrane.
Target Tissue Specificity
Found in the developing vertebral bodies, ribs, upper and lower limbs, heart, kidney, lung.
Target Synonyms
EVCEllis-van Creveld syndrome protein; DWF-1
Target Background
This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis.
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