Rabbit anti-Human EZH1 Polyclonal Antibody

The antibody against EZH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 160-280 of human EZH1 (NP_001982.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-11178A

Number

Cat.No	ADA-11178A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	EZH1
Target Synonyms	KMT6B; EZH1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse lung	Application	ELISA, WB

Cat.No

ADA-11178A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

EZH1

Target Synonyms

KMT6B; EZH1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse lung

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 160-280 of human EZH1 (NP_001982.2).	Target Species	Human
Immunogen Sequence	GEEEMIPGSVLISDAVFLELVDALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGP	Uniprot ID	Q92800

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 160-280 of human EZH1 (NP_001982.2).

Target Species

Human

Immunogen Sequence

GEEEMIPGSVLISDAVFLELVDALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGP

Uniprot ID

Q92800

Background Information

Uniprot Id

Q92800
Target Species

Human
Target Name

EZH1
Target Full Name

Histone-lysine N-methyltransferase EZH1
Target Function

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Target Subcellular Location

Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.
Target Protein Families

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily
Target Synonyms

Enhancer of zeste homolog 1 (Drosophila); Enhancer of zeste homolog 1; ENX-2; ENX2; Ezh1; EZH1_HUMAN; Histone-lysine N-methyltransferase EZH1
Target Background

EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).

Rabbit anti-Human EZH1 Polyclonal Antibody

Specifications

Immunogen Information

Inquire Rabbit anti-Human EZH1 Polyclonal Antibody Now

Related Products