Rabbit anti-Human FCRL5 Polyclonal Antibody

Uniprot Id

Q96RD9

Target Species

Human

Target Name

FCRL5

Target Full Name

Fc receptor-like protein 5

Target Function

May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.

Target Involvement

A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32).

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, iso

Target Research Area

Immunology

Target Synonyms

BXMAS1; CD307 antigen; CD307e; Fc receptor homolog 5; Fc receptor like 5; Fc receptor-like protein 5; FcR-like protein 5; FcRH5; FcRL5; FCRL5_HUMAN; Immune receptor translocation-associated protein 2; Immunoglobulin receptor translocation associated gene 2 protein; Immunoglobulin superfamily receptor translocation associated gene 2 protein; IRTA2; UNQ503/PRO820

Target Background

This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified.