Rabbit anti-Human FGF2 Monoclonal Antibody

The antibody against FGF2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 100-200 of human FGF2 (NP_001997.5) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-14921A

Number

Cat.No	ADA-14921A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	Fgf2
Target Synonyms	BFGF; FGFB; FGF-2; HBGF-2; FGF2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse ovary, Mouse spleen, Rat spleen, SKOV3	Application	ELISA, WB, IF/ICC

Cat.No

ADA-14921A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

Fgf2

Target Synonyms

BFGF; FGFB; FGF-2; HBGF-2; FGF2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse ovary, Mouse spleen, Rat spleen, SKOV3

Application

ELISA, WB, IF/ICC

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human FGF2 (NP_001997.5).	Target Species	Human
Immunogen Sequence	RAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAE	Uniprot ID	P09038

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human FGF2 (NP_001997.5).

Target Species

Human

Immunogen Sequence

RAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAE

Uniprot ID

P09038

Background Information

Uniprot Id

P09038
Target Species

Human
Target Name

FGF2
Target Full Name

Fibroblast growth factor 2
Target Function

Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation.
Target Subcellular Location

Secreted. Nucleus.
Target Protein Families

Heparin-binding growth factors family
Target Tissue Specificity

Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
Target Research Area

Signal Transduction
Target Synonyms

Basic fibroblast growth factor; Basic fibroblast growth factor bFGF; BFGF; FGF 2; FGF B; FGF-2; Fgf2; FGF2 basic; FGF2_HUMAN; FGFB; Fibroblast growth factor 2 (basic); Fibroblast growth factor 2; Fibroblast growth factor; basic; HBGF 2; HBGF-2; HBGF2; HBGH 2; HBGH2; Heparin binding growth factor 2 precursor; Heparin-binding growth factor 2; Prostatropin
Target Background

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.

Rabbit anti-Human FGF2 Monoclonal Antibody

Specifications

Immunogen Information

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