Rabbit anti-Human GIRK2(KCNJ6) Monoclonal Antibody

Uniprot Id

P48051

Target Species

Human

Target Name

KCNJ6

Target Full Name

G protein-activated inward rectifier potassium channel 2

Target Function

This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Target Involvement

Keppen-Lubinsky syndrome (KPLBS)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ6 subfamily

Target Tissue Specificity

Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas.

Target Synonyms

KCNJ6; GIRK2; KATP2; KCNJ7; G protein-activated inward rectifier potassium channel 2; GIRK-2; BIR1; Inward rectifier K(+ channel Kir3.2; KATP-2; Potassium channel, inwardly rectifying subfamily J member 6

Target Background

This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability.