Rabbit anti-Human GPT2 Polyclonal Antibody

Uniprot Id

Q8TD30

Target Species

Human

Target Name

GPT2

Target Full Name

Alanine aminotransferase 2

Target Function

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.

Target Involvement

Mental retardation, autosomal recessive 49 (MRT49)

Target Protein Families

Class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily

Target Tissue Specificity

Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast.

Target Research Area

Metabolism

Target Synonyms

AAT2; Alanine aminotransferase 2; ALAT2_HUMAN; ALT2; Glutamate pyruvate transaminase 2; Glutamic alanine transaminase 2; Glutamic pyruvate transaminase (alanine aminotransferase) 2; Glutamic pyruvic transaminase 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2; GPT 2; gpt2

Target Background

This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants.