Rabbit anti-Human GUCA1B Polyclonal Antibody

The antibody against GUCA1B was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GUCA1B (NP_002089.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-05481A

Number

Cat.No	ADA-05481A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	GUCA1B
Target Synonyms	RP48; GCAP2; GUCA2; GCAP 2; GUCA1B	Form	Liquid
Species Reactivity	Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse eye, Rat eye	Application	ELISA, WB

Cat.No

ADA-05481A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

GUCA1B

Target Synonyms

RP48; GCAP2; GUCA2; GCAP 2; GUCA1B

Form

Liquid

Species Reactivity

Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse eye, Rat eye

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GUCA1B (NP_002089.4).	Target Species	Human
Immunogen Sequence	MGQEFSWEEAEAAGEIDVAELQEWYKKFVMECPSGTLFMHEFKRFFKVTDDEEASQYVEGMFRAFDKNGDNTIDFLEYVAALNLVLRGTLEHKLKWTFKIYDKDGNGCIDRLELLNIVEGIYQLKKACRRELQTEQGQLLTPEEVVDRIFLLVDENGDGQLSLNEFVEGARRDKWVMKMLQMDMNPSSWLAQQRRKSAMF	Uniprot ID	Q9UMX6

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GUCA1B (NP_002089.4).

Target Species

Human

Immunogen Sequence

MGQEFSWEEAEAAGEIDVAELQEWYKKFVMECPSGTLFMHEFKRFFKVTDDEEASQYVEGMFRAFDKNGDNTIDFLEYVAALNLVLRGTLEHKLKWTFKIYDKDGNGCIDRLELLNIVEGIYQLKKACRRELQTEQGQLLTPEEVVDRIFLLVDENGDGQLSLNEFVEGARRDKWVMKMLQMDMNPSSWLAQQRRKSAMF

Uniprot ID

Q9UMX6

Background Information

Uniprot Id

Q9UMX6
Target Species

Human
Target Name

GUCA1B
Target Full Name

Guanylyl cyclase-activating protein 2
Target Function

Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure. May be involved in cone photoreceptor response and recovery of response in bright light.
Target Involvement

Retinitis pigmentosa 48 (RP48)
Target Subcellular Location

Cell membrane; Lipid-anchor. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment.
Target Tissue Specificity

In the retina, it is expressed in cone and rod photoreceptor cells.
Target Synonyms

GCAP 2; Guanylate Cyclase Activating Protein Photoreceptor 2; Guanylate cyclase activator 1B; Guanylin 2; Guanylyl cyclase-activating protein 2; GUC1B_HUMAN; GUCA 2; Guca1b
Target Background

The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa.

Rabbit anti-Human GUCA1B Polyclonal Antibody

Specifications

Immunogen Information

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