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The antibody against HAS3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 67-281 of human HAS3 (NP_619515.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against HAS3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 67-281 of human HAS3 (NP_619515.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09454A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HAS3 |
| Target Synonyms | HAS3 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Rat heart, A-549, HL-60, Rat liver, SKOV3, SW480 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 67-281 of human HAS3 (NP_619515.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O00219 | Immunogen Sequence |
Uniprot Id
O00219
Target Species
Human
Target Name
HAS3
Target Full Name
Hyaluronan synthase 3
Target Function
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction.
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
NodC/HAS family
Target Synonyms
HAS3; Hyaluronan synthase 3; Hyaluronate synthase 3; Hyaluronic acid synthase 3; HA synthase 3
Target Background
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants.
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