Rabbit anti-Human HBB Polyclonal Antibody

Uniprot Id

P68871

Target Species

Human

Target Name

HBB

Target Full Name

Hemoglobin subunit beta

Target Function

Involved in oxygen transport from the lung to the various peripheral tissues.; LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.

Target Involvement

Heinz body anemias (HEIBAN); Beta-thalassemia (B-THAL); Sickle cell anemia (SKCA); Beta-thalassemia, dominant, inclusion body type (B-THALIB)

Target Protein Families

Globin family

Target Tissue Specificity

Red blood cells.

Target Synonyms

ECYT6; CD113t-C; beta-globin; HBB

Target Background

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.