Rabbit anti-Human HMGB3 Polyclonal Antibody

Uniprot Id

O15347

Target Species

Human

Target Name

HMGB3

Target Full Name

High mobility group protein B3

Target Function

Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling.

Target Involvement

Microphthalmia, syndromic, 13 (MCOPS13)

Target Subcellular Location

Nucleus. Chromosome. Cytoplasm.

Target Protein Families

HMGB family

Target Tissue Specificity

Expressed predominantly in placenta.

Target Synonyms

chromosomal protein; Nonhistone; HMG4; High mobility group (nonhistone chromosomal) protein 4; High mobility group box 3 ; High mobility group protein 2a; High mobility group protein 4; High mobility group protein B3; High mobility group protein HMG4 ; HMG 4 ; HMG-2a; HMG-4; HMG2A; HMGB 3 ; Hmgb3; HMGB3_HUMAN; MGC90319; Non histone chromosomal protein; Nonhistone chromosomal protein HMG4

Target Background

This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants.