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The antibody against HN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-154 of human HN1 (NP_057269.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against HN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-154 of human HN1 (NP_057269.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-04624A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HN1 |
| Target Synonyms | HN1; ARM2; HN1A | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HT-29 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-154 of human HN1 (NP_057269.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MTTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPTEQPVRKNKMASNIFGTPEENQASWAKSAGAKSSGGREDLESSGLQRRNSSEASSGDFLDLKGEGDIHENVDTDLPGSLGQSEEKPVPAAPVPSPVAPAPVPSRRNPPGGKSSLVLG | Uniprot ID | Q9UK76 |
Uniprot Id
Q9UK76
Target Species
Human
Target Name
JPT1
Target Full Name
Jupiter microtubule associated homolog 1
Target Function
Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
JUPITER family
Target Tissue Specificity
Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Androgen regulated protein 2; Androgen-regulated protein 2; ARM2; Hematological and neurological expressed 1; Hematological and neurological expressed 1 protein; HN1; HN1_HUMAN; HN1A
Target Background
Located in nuclear membrane; nucleolus; and nucleoplasm.
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