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The antibody against HYAL1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 136-435 of human HYAL1 (NP_149349.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against HYAL1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 136-435 of human HYAL1 (NP_149349.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-02925A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HYAL1 |
| Target Synonyms | MPS9; NAT6; LUCA1; HYAL-1; HYAL1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | PC-3 | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 136-435 of human HYAL1 (NP_149349.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q12794 | Immunogen Sequence |
Uniprot Id
Q12794
Target Species
Human
Target Name
HYAL1
Target Full Name
Hyaluronidase-1
Target Function
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
Target Involvement
Mucopolysaccharidosis 9 (MPS9)
Target Subcellular Location
Secreted. Lysosome.
Target Protein Families
Glycosyl hydrolase 56 family
Target Tissue Specificity
Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node sp
Target Research Area
Cancer
Target Synonyms
HYAL 1; Hyal-1; HYAL1; HYAL1_HUMAN; Hyaluronidase 1; Hyaluronidase-1; Hyaluronoglucosaminidase 1; Hyaluronoglucosaminidase-1; Hyaluronoglucosaminidase1; LUCA 1; LUCA-1; LUCA1; Lung carcinoma protein 1; MGC45987; NAT6; Plasma hyaluronidase; Tumor suppressor LUCA 1
Target Background
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
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