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The antibody against INTS8 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 150-250 of human INTS8 (NP_060334.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against INTS8 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 150-250 of human INTS8 (NP_060334.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-07053A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | INTS8 |
| Target Synonyms | INT8; NEDCHS; C8orf52; INTS8 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, MCF7, Mouse lung, U-251MG | Application | ELISA, WB |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human INTS8 (NP_060334.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | AIRTIVQSSFPVKQAKPGPPQLSVMNQMQQEKELTENILKVLKEQAADSILVLEAALKLNKDLYVHTMRTLDLLAMEPGMVNGETESSTAGLKVKTEEMQC | Uniprot ID | Q75QN2 |
Uniprot Id
Q75QN2
Target Species
Human
Target Name
INTS8
Target Full Name
Integrator complex subunit 8
Target Function
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
Target Subcellular Location
Nucleus.
Target Protein Families
Integrator subunit 8 family
Target Synonyms
INTS8; C8orf52; Integrator complex subunit 8; Int8; Protein kaonashi-1
Target Background
This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants.
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