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The antibody against ISY1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human ISY1 (NP_001186398.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ISY1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human ISY1 (NP_001186398.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06006A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ISY1 |
| Target Synonyms | FSAP33; ISY1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, Mouse brain, Mouse thymus, NCI-H460, OVCAR3, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human ISY1 (NP_001186398.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9ULR0 | Immunogen Sequence |
Uniprot Id
Q9ULR0
Target Species
Human
Target Name
ISY1
Target Full Name
Pre-mRNA-splicing factor ISY1 homolog
Target Function
Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively. Required during the transition of embryonic stem cells (ESCs) from the naive to primed state. By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state. Involved in pre-mRNA splicing as component of the spliceosome
Target Subcellular Location
Nucleus.
Target Protein Families
ISY1 family
Target Synonyms
FSAP33; ISY1; ISY1 splicing factor homolog (S. cerevisiae); ISY1_HUMAN; KIAA1160; Pre-mRNA-splicing factor ISY1 homolog
Target Background
Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type catalytic step 1 spliceosome and catalytic step 2 spliceosome.
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