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The antibody against ITPKA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 141-461 of human ITPKA (NP_002211.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ITPKA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 141-461 of human ITPKA (NP_002211.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06913A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ITPKA |
| Target Synonyms | IP3KA; IP3-3KA; ITPKA | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 141-461 of human ITPKA (NP_002211.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P23677 | Immunogen Sequence |
Uniprot Id
P23677
Target Species
Human
Target Name
ITPKA
Target Full Name
Inositol-trisphosphate 3-kinase A
Target Synonyms
ITPKA; Inositol-trisphosphate 3-kinase A; EC 2.7.1.127; Inositol 1,4,5-trisphosphate 3-kinase A; IP3 3-kinase A; IP3K A; InsP 3-kinase A
Target Background
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1, 4, 5-trisphosphate to Ins(1, 3, 4, 5)P4. The activity of the inositol 1, 4, 5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.
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