Rabbit anti-Human KCNC4 Polyclonal Antibody

Uniprot Id

Q03721

Target Species

Human

Target Name

KCNC4

Target Full Name

Voltage-gated potassium channel KCNC4

Target Function

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Potassium channel family, C (Shaw) (TC 1.A.1.2) subfamily, Kv3.4/KCNC4 sub-subfamily

Target Synonyms

KV3.4; C1orf30; KSHIIIC; HKSHIIIC; KCNC4

Target Background

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene.