Rabbit anti-Human KIAA0319 Polyclonal Antibody

Uniprot Id

Q5VV43

Target Species

Human

Target Name

KIAA0319

Target Full Name

Dyslexia-associated protein KIAA0319

Target Function

Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites.

Target Involvement

Dyslexia 2 (DYX2)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in brain cortex, putamen, amygdala, hippocampus and cerebellum.

Target Synonyms

DLX 2; DLX2; DYLX 2; DYLX2; Dyslexia susceptibility 2; Dyslexia-associated protein KIAA0319; DYX 2; DYX2; K0319_HUMAN; Kiaa0319; MGC176717

Target Background

This gene encodes a transmembrane protein that contains a large extracellular domain with multiple polycystic kidney disease (PKD) domains. The encoded protein may play a role in the development of the cerebral cortex by regulating neuronal migration and cell adhesion. Single nucleotide polymorphisms in this gene are associated with dyslexia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.