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The antibody against KLC2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KLC2 (NP_073733.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against KLC2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KLC2 (NP_073733.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-07077A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KLC2 |
| Target Synonyms | KLC2; SPOAN | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain, Raji, Rat lung, Rat testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KLC2 (NP_073733.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MAMMVFPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAPEAGEAEPGSQERCILLRRSLEAIELGLGEAQVILALSSHLGAVES | Uniprot ID | Q9H0B6 |
Uniprot Id
Q9H0B6
Target Species
Human
Target Name
KLC2
Target Full Name
Kinesin light chain 2
Target Function
Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends.
Target Involvement
Spastic paraplegia, optic atrophy, and neuropathy (SPOAN)
Target Subcellular Location
Cytoplasm, cytoskeleton. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families
Kinesin light chain family
Target Synonyms
Kinesin light chain 2; KLC 2; KLC2; KLC2_HUMAN
Target Background
The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome.
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