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The antibody against M6PR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 27-185 of human M6PR (NP_002346.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against M6PR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 27-185 of human M6PR (NP_002346.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-07728A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | M6PR |
| Target Synonyms | SMPR; MPR46; CD-MPR; MPR 46; MPR-46; CD-M6PR; M6PR | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 27-185 of human M6PR (NP_002346.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | TEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISH | Uniprot ID | P20645 |
Uniprot Id
P20645
Target Species
Human
Target Name
M6PR
Target Full Name
Cation-dependent mannose-6-phosphate receptor
Target Function
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Target Subcellular Location
Lysosome membrane; Single-pass type I membrane protein.
Target Synonyms
M6PR; MPR46; MPRD; Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-MPR; 46 kDa mannose 6-phosphate receptor; MPR 46
Target Background
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.
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