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The antibody against MESDC2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human MESDC2 (NP_055969.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MESDC2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human MESDC2 (NP_055969.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05933A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MESDC2 |
| Target Synonyms | BOCA; OI20; MESDC2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Rat heart, A-431, HepG2, Mouse brain, SGC-7901 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human MESDC2 (NP_055969.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q14696 | Immunogen Sequence |
Uniprot Id
Q14696
Target Species
Human
Target Name
MESD
Target Full Name
LRP chaperone MESD
Target Function
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
Target Subcellular Location
Endoplasmic reticulum.
Target Protein Families
MESD family
Target Synonyms
BOCA; KIAA0081; LDLR chaperone MESD; MESD; MESD_HUMAN; MESDC 2 ; mesdc2; Mesoderm development candidate 2; Mesoderm development protein; Renal carcinoma antigen NY REN 61; Renal carcinoma antigen NY-REN-61
Target Background
Predicted to enable low-density lipoprotein particle receptor binding activity. Involved in ossification and protein folding. Located in endoplasmic reticulum. Implicated in osteogenesis imperfecta type 20.
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